Genomap

Genomap is an entropy-based cartography strategy to contrive the high dimensional gene expression data into a configured image format, referred to as genomap, with explicit integration of the genomic interactions. This unique cartography casts the gene-gene interactions into the spatial configuration of genomaps and enables us to extract the deep genomic interaction features and discover underlying discriminative patterns of the data. For a wide variety of applications (cell clustering and recognition, gene signature extraction, single-cell data integration, cellular trajectory analysis, dimensionality reduction, and visualization), the proposed approach drastically improves the accuracy of data analyses as compared to the state-of-the-art techniques.

Reference: Islam MT, Xing L. Cartography of Genomic Interactions Enables Deep Analysis of Single-Cell Expression Data. Nature Communications. 2023 Feb 8;14(1):679.